In the context of neurotoxicity, NK1R is crucial due to its involvement in the regulation of neurotransmitter release and neuroinflammation. Activation of NK1R can lead to increased levels of excitatory neurotransmitters, such as glutamate, which can result in excitotoxicity and neuronal damage. This makes NK1R a potential target for therapies aiming to mitigate neurotoxic effects.
