How is NK1R Targeted in Therapeutic Interventions?
Targeting NK1R has therapeutic potential in treating various disorders, including depression, anxiety, and chronic pain. Antagonists of NK1R, such as aprepitant, are used to manage chemotherapy-induced nausea and vomiting by inhibiting the receptor's ability to bind substance P. This therapeutic approach highlights the receptor's role in communication between the brain and gastrointestinal system.
