What Role Does Toxicology Play in GRAS Determinations?
Toxicology plays a critical role in GRAS determinations as it provides the scientific basis for safety assessments. Toxicologists examine various factors such as the dose-response relationship, absorption, distribution, metabolism, and excretion of the substance. They also consider potential adverse effects, including carcinogenicity, mutagenicity, and reproductive toxicity. These evaluations help determine the safety margins and acceptable levels of consumption.
