What Types of Models are Used in Toxicology Simulations?
Several types of models are utilized in toxicology simulations, including QSAR models, pharmacokinetic and pharmacodynamic (PK/PD) models, and PBPK models. QSAR models predict the toxicity of chemicals based on their molecular structure and have been extensively used in regulatory toxicology. PK/PD models help in understanding the absorption, distribution, metabolism, and excretion (ADME) of substances. PBPK models simulate how chemicals move through the body, offering insights into potential toxicological effects across different species.
