ILE therapy is primarily used in cases of overdose with lipophilic drugs. Some common indications include:
- Local Anesthetic Systemic Toxicity (LAST): This was one of the first and most successful applications of ILE. It is particularly effective in treating cardiotoxicity induced by local anesthetics like bupivacaine.
- Beta-Blocker and Calcium Channel Blocker Overdose: While not universally effective for all cases, it has been used as an adjunctive treatment when conventional therapies fail.
- Tricyclic Antidepressant Overdose: Due to their high lipid solubility, ILE can be considered in severe tricyclic antidepressant toxicity.
