TIG is administered in cases of potential exposure to tetanus, especially when a person has sustained a wound that is at risk of contamination with Clostridium tetani spores. It is particularly important for individuals who have an uncertain vaccination history or those who have not completed the primary series of tetanus vaccinations. In the context of toxicology, TIG is crucial because tetanus toxin can lead to severe neurological complications and even death if not promptly neutralized.