The Ah receptor is of particular interest in toxicology due to its role in mediating the toxic effects of several environmental contaminants. These include dioxins, PCBs, and polycyclic aromatic hydrocarbons (PAHs), which are often byproducts of industrial processes and combustion. The activation of the Ah receptor by such compounds can lead to adverse effects like carcinogenesis, immunotoxicity, and disruption of endocrine function. By studying the Ah receptor, toxicologists can better understand the mechanisms underlying these toxic effects and assess the risk posed by environmental pollutants.
