Urine alkalinization is indicated in cases of poisoning or overdose with substances that are weak acids. These include:
1. Salicylate poisoning: Overdose of aspirin can lead to severe toxicity, and urine alkalinization can help in its rapid elimination. 2. Phenobarbital overdose: This barbiturate is more effectively excreted in an alkaline urine. 3. Methotrexate toxicity: High-dose methotrexate therapy can lead to toxicity, and increasing urine pH can help in its clearance.
