Which Enzymes are Involved in First Pass Metabolism?
The liver contains a variety of enzymes that facilitate first pass metabolism, including cytochrome P450 enzymes, flavin-containing monooxygenases, and conjugation enzymes such as UDP-glucuronosyltransferases. Cytochrome P450 enzymes are particularly noteworthy as they play a significant role in the oxidative metabolism of many xenobiotics and drugs. Variations in these enzymes among individuals can lead to differences in drug metabolism and therapeutic outcomes.
