How Does Genetic Variation Influence First Pass Metabolism?
Genetic polymorphisms in metabolic enzymes can lead to significant variability in first pass metabolism among individuals. Some people may be poor metabolizers, leading to increased drug exposure and potential toxicity, while others may be ultra-rapid metabolizers, reducing drug efficacy. Personalized medicine approaches, which take into account an individual's pharmacogenomics, are increasingly used to optimize drug dosing and minimize adverse effects.
