Several toxins are well-documented for their axonal toxicity. These include:
1. Heavy Metals: Mercury and lead are notorious for causing axonal damage. They interfere with the normal functioning of neurons and can lead to long-term neurological deficits.
2. Organophosphates: Commonly found in pesticides, they can induce a condition known as organophosphate-induced delayed neuropathy (OPIDN), characterized by axonal degeneration.
3. Alcohol: Chronic alcohol abuse leads to peripheral neuropathy, where axonal degeneration is a significant factor.
4. Chemotherapeutic Agents: Drugs like vincristine and cisplatin, used in cancer treatment, can cause peripheral neuropathy through axonal damage.
