In toxicology, fast acetylators refer to individuals who metabolize certain drugs and environmental chemicals at a quicker pace due to their genetic makeup. This rapid metabolism is primarily related to the activity of the N-acetyltransferase enzyme (NAT), particularly the NAT2 gene, which is responsible for the acetylation process. Fast acetylators carry variations of this gene that enhance their ability to transfer acetyl groups to substrates, leading to quicker biotransformation and elimination of drugs from the body.
