Why are Hydroxyl Radicals Significant in Toxicology?
The significance of hydroxyl radicals in toxicology stems from their ability to cause extensive cellular damage. They can react with DNA, proteins, lipids, and other biomolecules, leading to mutations, enzyme dysfunction, and membrane disruption. This damage can trigger cell death pathways such as apoptosis or necrosis, contributing to various pathological conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders.
