The variability in human responses to toxins can be attributed to several factors:
Genetic Differences: Variations in genes can influence how individuals metabolize and eliminate toxins. For example, polymorphisms in metabolic enzymes like cytochrome P450 can lead to increased or decreased detoxification efficiency. Age and Sex: Age-related changes in liver and kidney function, along with hormonal differences between sexes, can affect the body's ability to process toxins. Health Status: Pre-existing health conditions, such as liver or kidney disease, can alter how toxins are metabolized and excreted. Environmental Exposures: Lifestyle choices, including diet, alcohol consumption, and smoking, can modulate the body's response to toxins.