Why Do People Respond Differently to Toxic Substances?
Several factors contribute to the variability in human response:
1. Genetic Differences: Genetic polymorphisms can influence how substances are metabolized. For instance, variations in the CYP450 enzymes can lead to differences in drug metabolism. 2. Age: Neonates, children, adults, and the elderly may have different susceptibilities due to varying metabolic rates and functional maturity of organs. 3. Gender: Hormonal differences can affect how toxins are processed in the body. 4. Health Status: Pre-existing medical conditions can modify how a body responds to toxic substances. 5. Lifestyle: Factors like diet, smoking, and alcohol consumption can alter metabolic pathways. 6. Environmental Exposures: Concurrent exposure to other chemicals can lead to interactions that affect toxicity.
