There are several reasons why therapeutic failure might occur in toxicology:
Incorrect Diagnosis: If the toxic agent is misdiagnosed, the treatment administered may not be appropriate for the actual toxin involved. Drug Interactions: Concurrent administration of multiple drugs can lead to interactions that either reduce the efficacy of a treatment or increase toxicity. Patient Compliance: Non-adherence to prescribed treatment protocols can lead to suboptimal therapeutic outcomes. Pharmacokinetics: Individual differences in metabolism and absorption can affect drug levels, leading to insufficient therapeutic concentrations. Resistance Developments: Over time, certain toxins may develop resistance to therapeutic agents.