BPDE is significant in toxicology due to its role as a DNA-damaging agent. BPDE forms covalent bonds with DNA, resulting in the formation of BPDE-DNA adducts. These adducts can cause mutations during DNA replication if not repaired properly, leading to carcinogenesis. BPDE is thus a key player in the study of chemical carcinogenesis, especially in the context of exposure to PAHs.
