How does Fas (CD95) relate to toxicological effects?
The Fas receptor is crucial in mediating the toxicological responses to various chemical agents and environmental stressors. For instance, some toxicants can upregulate Fas expression, leading to increased sensitivity to apoptosis and tissue damage. Conversely, resistance to Fas-mediated apoptosis can result in the survival of damaged or transformed cells, contributing to cancer development. Understanding these dynamics is key to evaluating the risks associated with chemical exposures.
