Why is Cytochrome P450 14α-Demethylase Important in Toxicology?
Understanding CYP51's role is critical in toxicology due to its implications in drug interactions and toxicity. Inhibitors of CYP51, such as azole antifungals, disrupt ergosterol synthesis, leading to increased membrane permeability and ultimately, fungal cell death. However, these inhibitors can also interact with human cytochrome P450 enzymes, leading to potential side effects and toxicological concerns.
