Why is γ H2AX Foci Formation Important in Toxicology?
In toxicology, the formation of γ H2AX foci is a crucial biomarker for assessing genotoxicity and the potential of chemicals, environmental toxins, and pharmaceuticals to induce DNA damage. The presence of γ H2AX foci indicates that the cellular DNA has undergone DSBs, which can lead to mutations, cancer, and cell death if not properly repaired.
