1. Population Differences: Different populations may exhibit varying levels of susceptibility to toxins due to genetic, nutritional, and lifestyle factors. For instance, certain populations may have genetic polymorphisms that affect the metabolism of toxic substances. 2. Environmental Factors: Environmental conditions such as climate, soil composition, and industrial activities can influence the presence and concentration of toxins. Environmental factors can also impact the bioavailability and degradation rates of toxic substances. 3. Regulatory Standards: Local validity ensures that regulatory guidelines and safety standards are appropriate for the specific context in which they are applied. This is essential for the development of effective public health policies and interventions.
