In toxicology, physostigmine is primarily used as an antidote for anticholinergic toxicity. Anticholinergic toxicity can result from the ingestion of substances such as atropine, scopolamine, and certain antihistamines or tricyclic antidepressants. Symptoms include delirium, hallucinations, tachycardia, and dry mucous membranes. Physostigmine can cross the blood-brain barrier, making it effective in reversing central nervous system effects of anticholinergic agents.
