Nerium oleander - Toxicology


Nerium oleander is a highly toxic plant widely cultivated for its ornamental beauty. It is known for its beautiful flowers and is commonly found in many parts of the world, particularly in subtropical and temperate regions. Despite its aesthetic appeal, every part of the plant is toxic, and it poses significant health risks if ingested or improperly handled.

What makes Nerium oleander toxic?

The toxicity of Nerium oleander is primarily due to the presence of cardiac glycosides, notably oleandrin and neriine. These compounds exert potent effects on the heart, leading to their classification as cardiotoxins. Cardiac glycosides inhibit the sodium-potassium pump in cell membranes, which can result in cardiac arrhythmias, potentially leading to fatal outcomes.

What are the symptoms of Nerium oleander poisoning?

Symptoms of Nerium oleander poisoning can vary depending on the dose and route of exposure. Common symptoms include nausea, vomiting, abdominal pain, diarrhea, and dizziness. In severe cases, there may be bradycardia, tachycardia, or other serious cardiac arrhythmias, which can lead to heart block or even death. Neurological symptoms such as confusion, drowsiness, or seizures may also occur.

How is Nerium oleander poisoning diagnosed?

Diagnosis of Nerium oleander poisoning is primarily based on the history of exposure and clinical symptoms. Laboratory tests can detect elevated levels of cardiac glycosides in the blood. Electrocardiograms (ECGs) are essential for identifying cardiac abnormalities such as arrhythmias. In some cases, a specific blood test can measure oleandrin levels to confirm poisoning.

What is the treatment for Nerium oleander poisoning?

Treatment of Nerium oleander poisoning is largely supportive. In cases of recent ingestion, activated charcoal may be administered to prevent further absorption of the toxin. Continuous monitoring of cardiac function is crucial, and symptomatic treatment of arrhythmias may involve atropine for bradycardia or other antiarrhythmic drugs as necessary. In severe cases, digoxin-specific antibody fragments (Digibind) may be used to neutralize the effects of the cardiac glycosides.

How can exposure to Nerium oleander be prevented?

Prevention of exposure to Nerium oleander involves public education about its hazards. Individuals should be advised not to ingest any part of the plant and to prevent children and pets from accessing it. When handling the plant, use gloves to avoid skin irritation, and wash hands thoroughly afterward. Proper disposal of plant material is also important to prevent accidental ingestion by animals.

Are there any beneficial uses of Nerium oleander?

Despite its toxicity, some studies have investigated the potential therapeutic uses of Nerium oleander extracts. These include research into its anticancer properties and effectiveness against certain viral infections. However, such uses are experimental, and due to the plant's toxicity, any medicinal use should be approached with caution and under professional guidance.

Conclusion

Nerium oleander is a plant with significant toxicological importance due to its cardiac glycosides. While it is often admired for its beauty, it poses serious risks to human and animal health. Understanding the symptoms, treatments, and preventive measures is essential for safely coexisting with this plant. Caution and awareness are key to preventing accidental poisonings.



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Issue Release: 2023

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