What are the Types of 3D Cell Models Used in Toxicology?
Several types of 3D cell models are employed in toxicology, including organoids, spheroids, and tissue-engineered constructs:
Organoids: Miniaturized and simplified versions of organs, organoids are derived from stem cells and can self-organize to form structures similar to their in vivo counterparts. They are incredibly useful for studying organ-specific toxicity. Spheroids: These are aggregates of cells that form a spherical shape, closely mimicking the 3D structure of tumors. Spheroids are particularly valuable in cancer toxicology studies. Tissue-Engineered Constructs: These models are developed by combining cells with engineered materials to create tissues. They are used to study the toxicological effects on various organ systems.
