Are There Any Limitations to Using ESCs in Toxicology?
Despite their advantages, the use of ESCs in toxicology is not without challenges. One significant limitation is the complexity of replicating the in vivo environment within an in vitro setting. ESCs may not fully capture the interactions and systemic responses present in a whole organism. Additionally, the process of differentiating ESCs into specific cell types can be intricate and may result in heterogeneous populations, potentially affecting the reliability of results. Furthermore, ethical concerns regarding the use of human ESCs continue to be a topic of debate.
