Deoxyguanosine is particularly important in toxicology because it is a target for oxidative stress and other forms of DNA damage. Exposure to reactive oxygen species (ROS) and certain chemical agents can result in the modification of deoxyguanosine, leading to mutagenic lesions such as 8-oxo-deoxyguanosine. These modifications can cause mutations if not repaired, potentially leading to carcinogenesis and other health issues.
