Are There Environmental and Lifestyle Factors that Affect NAT2 Activity?
Yes, environmental and lifestyle factors can influence NAT2 activity. Diet, smoking, and exposure to certain chemicals can modulate the expression and activity of NAT2. For example, cruciferous vegetables contain compounds that can induce NAT2 activity, while smoking introduces aromatic amines that NAT2 must metabolize, potentially overwhelming the enzyme in slow acetylators.
