What Are the Toxicological Implications of Lipid Accumulation?
Lipid accumulation in Niemann-Pick Disease has several toxicological implications. The build-up of lipids can disrupt cellular functions, leading to oxidative stress, inflammation, and apoptosis. These processes can be exacerbated by exposure to environmental toxins, which may further impair cellular function. Additionally, lipid-laden cells may have altered cellular signaling pathways, affecting the body's response to toxic insults. Toxicologists must consider these factors when assessing the risk and developing treatment strategies for individuals with Niemann-Pick Disease.
