In rare cases, H2 receptor antagonists can cause more serious adverse reactions, such as arrhythmias, confusion, and depression, particularly in the elderly or those with renal impairment. High doses or chronic use can potentially lead to hepatotoxicity and nephrotoxicity. Moreover, Ranitidine has been under scrutiny due to the presence of N-nitrosodimethylamine (NDMA), a probable human carcinogen, leading to recalls and a shift towards alternative therapies.
