Can TNFR1 be a Target for Reducing Toxicological Effects?
Yes, targeting TNFR1 has therapeutic potential for reducing toxicological effects. Inhibiting TNFR1 or its downstream signaling can mitigate the harmful effects of excessive inflammation or cell death induced by toxins. For instance, TNF inhibitors, which block TNF-α from binding to TNFR1, are already used in treating chronic inflammatory diseases. These inhibitors could potentially be repurposed or refined to prevent or reduce damage from toxic exposures.
