Are There Special Considerations for Specific Populations?
Certain populations may have an increased risk of sevoflurane-related toxicities. For instance, pediatric patients and the elderly may exhibit enhanced sensitivity to the anesthetic effects, necessitating careful dose adjustments. Patients with pre-existing renal impairment may require closer monitoring and alternative anesthetic options may be considered. Additionally, genetic factors influencing the activity of enzymes involved in sevoflurane metabolism, such as polymorphisms in the CYP2E1 gene, can affect susceptibility to toxicity.
