Can ALDH2 Be Targeted for Therapeutic Interventions?
Yes, targeting ALDH2 for therapeutic interventions is an area of active research. Compounds that enhance ALDH2 activity or mimic its function can potentially mitigate the toxic effects of aldehyde accumulation. For example, Alda-1 is a small molecule activator of ALDH2 that has shown promise in preclinical studies for reducing aldehyde-induced cellular damage and improving cardiovascular health.
