What Are the Toxicological Implications of ALDH2 Deficiency?
ALDH2 deficiency has several toxicological implications. The accumulation of acetaldehyde can cause DNA damage, protein adduct formation, and lipid peroxidation, contributing to various pathologies, including liver cirrhosis, cardiovascular diseases, and neurodegenerative disorders. Understanding these mechanisms is crucial for developing targeted interventions for individuals with ALDH2 deficiency.
