Preventing and managing chronic inflammation requires addressing the underlying causes and implementing lifestyle changes. Reducing exposure to known toxicants and adopting an anti-inflammatory diet rich in antioxidants can mitigate the effects of chronic inflammation. Pharmacological interventions, including the use of anti-inflammatory drugs and biologics, may also be necessary to control inflammation and prevent disease progression. In the field of toxicology, regulatory measures to limit environmental and occupational exposure to harmful chemicals are critical for prevention.