Can Enzyme Polymorphisms Affect Environmental Exposures?
Yes, enzyme polymorphisms can influence how individuals respond to environmental pollutants. For instance, variations in Paraoxonase (PON1) can affect the detoxification of organophosphate pesticides, impacting susceptibility to neurotoxic effects. Similarly, polymorphisms in Aldehyde Dehydrogenase (ALDH) can modulate the risk of alcohol-induced health issues due to differences in the metabolism of acetaldehyde, a toxic metabolite of alcohol.
