What Are the Challenges in Studying Enzyme Polymorphisms?
One of the key challenges in studying enzyme polymorphisms is the complexity of gene-environment interactions. The effects of polymorphisms can be modulated by environmental factors, such as diet, lifestyle, and co-exposure to other chemicals. Additionally, the presence of multiple polymorphisms in a single metabolic pathway can complicate predictions of metabolic capacity and toxicity. Therefore, comprehensive studies that integrate genetic, environmental, and lifestyle factors are essential to fully understand the implications of enzyme polymorphisms.
