Can Genetic Factors Influence Susceptibility to Dopaminergic Toxicity?
Genetic predispositions can significantly influence an individual's susceptibility to dopaminergic toxicity. Variations in genes encoding for dopamine receptors, transporters, and metabolic enzymes can affect how toxins interact with the dopaminergic system. For instance, polymorphisms in the dopamine transporter gene (DAT1) can alter dopamine uptake efficiency, modifying the system's vulnerability to toxic insults.
