Yes, glycoproteins significantly influence drug toxicity. P-glycoprotein, a well-studied multidrug resistance protein, can affect the bioavailability and toxicity of various drugs. By pumping drugs out of cells, it can decrease drug efficacy and impact therapeutic outcomes. This is particularly important in cancer therapy, where the overexpression of P-glycoprotein in cancer cells can lead to multidrug resistance, making treatment less effective and altering the toxicological profile of chemotherapeutic agents.
