Yes, certain medications are known to be ototoxic and can cause hearing loss. Aminoglycoside antibiotics, such as gentamicin, and some chemotherapy agents, like cisplatin, are well-documented for their ototoxic effects. The mechanism typically involves damage to the hair cells in the cochlea or the auditory nerve. Healthcare providers should weigh the benefits and risks of these medications and consider alternative treatments or monitoring protocols to minimize potential auditory damage.