While it may not be possible to entirely prevent off-target effects, several strategies can minimize their occurrence. Rational drug design aims to enhance selectivity for the intended target, thereby reducing the likelihood of off-target interactions. Structure-activity relationship (SAR) studies can help in modifying the chemical structure to improve specificity. Additionally, personalized medicine approaches consider individual genetic factors that might predispose a person to off-target effects, allowing for tailored therapeutic regimens.
