How are Aromatic Compounds Metabolized in the Body?
Once absorbed into the body, aromatic compounds undergo metabolic transformation, primarily in the liver. Enzymes such as cytochrome P450 play a crucial role in this process, converting aromatic compounds into more water-soluble metabolites that can be excreted. However, some metabolites may be more toxic than the parent compound, as seen with benzene, which is metabolized into reactive intermediates that can cause DNA damage and lead to carcinogenesis.