How are Naturally Occurring Compounds Assessed for Toxicity?
The assessment of naturally occurring compounds involves several key steps:
Identification: Using techniques such as mass spectrometry and chromatography to determine the chemical structure of the compound. Exposure Assessment: Evaluating how humans and animals are exposed to the compound, including dietary exposure, inhalation, and skin contact. Toxicity Testing: Conducting animal studies and in vitro assays to determine toxic effects, dose-response relationships, and mechanisms of toxicity. Risk Assessment: Integrating data to assess the likelihood and severity of adverse effects in humans, considering factors such as age, sex, and genetics.
