Diagnosing an overactive immune response involves a combination of clinical evaluation and laboratory tests. Blood tests can measure levels of antibodies and specific markers of inflammation, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Allergy tests, like skin prick tests and serum-specific IgE tests, help identify potential allergens. For autoimmune diseases, tests for specific autoantibodies are conducted to confirm the diagnosis.