The development of quantitative risk estimates involves a series of steps, including hazard identification, dose-response assessment, exposure assessment, and risk characterization.
Hazard Identification: This step involves determining whether a substance has the potential to cause harm based on available scientific evidence. Dose-Response Assessment: This involves characterizing the relationship between the dose of a substance and the incidence of adverse health effects. Exposure Assessment: This step estimates the magnitude, frequency, and duration of human exposure to the substance. Risk Characterization: Finally, risk characterization integrates data from the previous steps to provide a comprehensive estimate of the risk.