RCTs in toxicology follow a structured methodology. They begin with a clearly defined research question and a detailed study protocol that outlines the inclusion and exclusion criteria for participants, the randomization process, and the statistical methods to be used. Participants are then randomly assigned to receive either the experimental treatment or a placebo/control. Throughout the trial, data is collected on various outcomes, such as toxicity levels, biochemical markers, and clinical symptoms, to assess the safety and efficacy of the intervention.