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safety margins
How are Safety Margins Calculated?
Safety margins are typically calculated using data from
dose-response relationships
. This involves determining the
No Observable Adverse Effect Level (NOAEL)
or the
Lowest Observable Adverse Effect Level (LOAEL)
from animal studies or clinical trials. The NOAEL or LOAEL is then divided by a series of
uncertainty factors
to account for differences between species, variability within human populations, and other uncertainties. The resulting value is the
Reference Dose (RfD)
or
Acceptable Daily Intake (ADI)
.
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