safety margins

How are Safety Margins Calculated?

Safety margins are typically calculated using data from dose-response relationships. This involves determining the No Observable Adverse Effect Level (NOAEL) or the Lowest Observable Adverse Effect Level (LOAEL) from animal studies or clinical trials. The NOAEL or LOAEL is then divided by a series of uncertainty factors to account for differences between species, variability within human populations, and other uncertainties. The resulting value is the Reference Dose (RfD) or Acceptable Daily Intake (ADI).

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