Toxic substances are regulated through a combination of legislation and guidelines set by national and international bodies. In the United States, for example, the Environmental Protection Agency (EPA) plays a significant role in regulating chemicals under laws such as the Toxic Substances Control Act (TSCA). Similarly, the European Union regulates chemicals through the REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals) framework. These regulations require companies to provide data on the safety and efficacy of chemicals before they can be marketed or used.