Alcohol and recreational drugs can also play a significant role in depression. While these substances may initially provide temporary relief from depressive symptoms, they can ultimately worsen the condition. Chronic alcohol use, for instance, can lead to brain damage, nutrient deficiencies, and hormonal imbalances, all of which can exacerbate depression. Similarly, drugs such as cocaine and methamphetamine can cause severe changes in brain chemistry, leading to depressive episodes during withdrawal periods.
