plasma protein binding

How Can Changes in Plasma Protein Binding Influence Toxicity?

Changes in plasma protein binding can significantly impact toxicity. An increase in the free fraction of a toxicant can lead to enhanced distribution to target tissues, greater interaction with cellular components, and increased toxic effects. Conversely, a decrease in the free fraction can reduce toxicity but may also affect the therapeutic efficacy of drugs.

Frequently asked queries:

What is Plasma Protein Binding?
Why is Plasma Protein Binding Important in Toxicology?
How Does Plasma Protein Binding Affect Distribution?
What Factors Influence Plasma Protein Binding?
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How is Plasma Protein Binding Measured?
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How Does Disease Affect Plasma Protein Binding?
How Can Changes in Plasma Protein Binding Influence Toxicity?
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