How Can Disruption in Nucleotide Synthesis Lead to Disease?
Disruptions in nucleotide synthesis can lead to an array of diseases including cancer, immunodeficiency, and neurological disorders. For instance, impaired nucleotide synthesis can cause the accumulation of toxic intermediates or the depletion of essential nucleotides, contributing to cell death or uncontrolled cell proliferation. Understanding these disruptions is vital for developing therapeutic interventions and assessing the toxicity of compounds.
